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KMID : 1007320070130010021
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Journal of the Korean Society of Menopause
2007 Volume.13 No. 1 p.21 ~ p.32
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Relationship between Low Density Lipoprotein Receptor-related Protein 5 Gene Single Nucleotide Polymorphism and Bone Mineral Density in Postmenopausal Korean Women
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Kim Ja-Yeon
Lee Dong-Ok
Jee Byung-Chul
Suh Chang-Suk
Kim Seok-Hyun
Choi Young-Min
Moon Shin-Yong
Kim Jung-Gu
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Abstract
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Objectives: To investigate the relationship between low density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms and bone mineral density (BMD) in postmenopausal Korean women.
Methods: The A314G, T2268C, and G Inv17-30 A polymorphisms in LRP5 gene were analyzed by restriction fragment length polymorphism in 261 postmenopausal Korean women. Serum CrossLaps (CTX), bone alkaline phosphatase (BAP), osteocalcin, parathyroid hormone (PTH), calcitonin, calcium, and phosphorus levels were measured by enzyme linked immunosorbent assay, immunoassay and by atomic absorptiometry respectively. The BMD at the lumbar spine and proximal femur was determined by dual energy X-ray absorptiometry.
Results: The distributions of A314G, T2268C, and G Inv17-30 A polymorphisms in LRP5 gene were as follows; AA 83.1%, AG 14.9%, GG 1.9%, CC 50.2%, CT 43.3%, TT 6.5%, GG 76.2%, GA 20.7%, and AA 3.1%. No significant differences in adjusted BMD of lumbar spine and femoral neck were noted among single or haplotype genotypes of LRP5 gene polymorphisms. No statistical significances in associations between serum levels of bone biochemical markers except PTH and single or haplotype genotypes were observed. Serum PTH levels in women with GG genotype of A314G polymorphism was significantly higher than those in women with AA or AG genotype.
Conclusion: The A314G, T2268C, and G Inv17-30 A polymorphisms in LRP5 gene do not affect BMD at the lumbar spine and proximal femur in postmenopausal Korean women.
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KEYWORD
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Postmenopausal women, LRP5 gene, Polymorphism, BMD
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